Finding a “treatment” for cancer has lately gotten replaced as a priority to control tumor growth, transforming cancer into a chronic disease with increased life expectancy and quality of life. Although this method has been beneficial in some cancers, average survival has only increased by roughly 15% in glioblastoma, one of the most aggressive tumors, during the last 20 years.
Moreover, Cannabidiol (CBD) oil, which is thought to be a great way of treating cancers, is becoming extremely prevalent. It’s now available at the local grocery store, pharmacy, and even health club, while it was once only accessible at novelty or vitamin stores. It comes in various forms, including oils placed under the tongue, skin roll-ons, and even vaping solutions. CBD oil in UK is extracted and mixed into foods to make edible goods.
But, exactly, what is CBD oil, and how does it help glioblastoma patients? Is it truly capable of treating, if not curing, or alleviating its symptoms? Let’s discuss it in the article.
What does CBD Oil mean?
CBD is among the numerous cannabinoids present in a flowering cannabis plant. CBD lacks tetrahydrocannabinol’s psychoactive (mind-altering) properties. A chemical present in cannabis (THC) is the component that causes a “high” in people. On the other hand, some people use CBD oil to help with pain, anxiety, and sleep problems.
CBD is derived from cannabis-based oil. CBD oil gets derived from hemp, which is a cannabis plant that contains high CBD content and a low THC content. Moreover, Cannabis plants are referred to as marijuana with high THC content. The oil can then get consumed as a liquid, a pill, a candy, or vaped. It can also be present in lotions and skin patches as an ingredient.
There’s still a lot we don’t know about cannabidiol. Since it got classified as a Schedule I substance by the United Kingdom Drug Enforcement Administration in 2018, it has remained chiefly unstudied (DEA). A schedule I substance is one that the DEA has classified unlawful due to safety concerns about its potential for misuse and the lack of a recognized medical use. The DEA then changed CBD’s classification to schedule V in September 2018. Schedule V medications have a lower risk of abuse and are thought to have medical applications.
What Is Glioblastoma?
Despite current treatment options such as chemotherapy and radiotherapy, glioblastoma remains one of the fatal cancers. The cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) from Cannabis sativa are two compounds that have shown to be helpful against this form of cancer. These link to specific transmembrane proteins present on the surface of glioblastoma cells. Thus, allowing them to enter the cells more efficiently. Cannabinoids enter the body and disrupt particular metabolic processes, causing tumor cells to stop growing, invade, and die.
Glioblastoma, the primary brain tumor, is also the most prevalent cancer. Treatment is challenging because of its high growth rate and severity and molecular and cellular diversity. Moreover, surgery, chemotherapy, radiation, and combinations of these are some of the current treatment options. Temozolomide (TMZ) is the gold standard for treatment. The median survival after second-line treatment with TMZ ranges from 5.1 to 13 months, depending on the study. However, antitumoral resistance to TMZ is common, contributing to the poor prognosis.
Symptoms of the Disease
Glioblastoma patients experience symptoms quickly due to the tumor’s mass effect or the fluid surrounding the tumor, thus causing more brain enlargement. Increased brain pressure, for example, is tied to a slew of symptoms at the initial diagnosis (nausea and severe headaches, which are typically worse in the morning).
Patients may also experience neurological symptoms that vary depending on the tumor’s location (for example, facial weakness or sensory alterations and neurocognitive/memory impairments). Seizures are another typical complication.
How does CBD Help with Glioblastoma?
CBD lowers the chronic inflammation linked with glioblastoma growth; this form of inflammation happens when the immune system becomes “confused” by the surroundings and tries to defend the malignant growth by mistake. CBD has been shown to inhibit the enzyme apelin reaction to glioblastoma growth, indicating that it is a practical tumor.
In most circumstances, apelin is present in tiny amounts in the brain, but it gets expressed in glioblastoma at a considerably higher level. Higher apelin levels promote tumor formation and blood vessel growth, whereas CBD slows the growth of fatal brain tumors and blocks immunological checkpoints.
Researchers consider CBD oil a safe and effective form of delivery that one can use as an alternative to invasive brain surgery for tumor removal.
Cannabidiol (CBD) could be an effective therapeutic for glioblastoma, according to findings from new research examining human and canine brain cancer cells. The administration mechanism ensures that CBD reaches the brain and is simple to utilize for most people. However, more research and therapy options for people with brain cancer remain highly required. The studies suggest that CBD has the potential to be helpful in synergistic glioblastoma treatment options and that it should get further investigated.
Is CBD safe for Glioblastoma patients?
You could come across reports on the web about the effects of CBD oil as a cancer treatment or as a side effect reliever. Please keep in mind that, while well-intentioned, such personal stories are not scientifically validated and do not serve as evidence. Large, standardized, controlled clinical trials are still required to verify CBD’s safety and efficacy in cancer patients.
It’s also worth noting that CBD has been proven in certain studies to interact with the way your body absorbs cancer medications, a phenomenon called drug interaction. This could increase the toxicity of cancer treatments or reduce their efficacy. These consequences also require more research.
You might also be curious about whether CBD is legal in your area. For medical and recreational purposes, certain states limit the availability and possession of cannabis, including CBD and THC. Others have more strict requirements, so it’s always good to research state-by-state laws before shipping CBD across state borders. At the federal level, things get more complex. In addition to CBD oil, hemp helps create rope and garments, which means hemp is no longer a controlled substance, meaning it is not subject to government regulation.
Overall, while research on CBD treatment for glioblastoma has been encouraging, it is still in its early phases. Glioblastoma is a disease with numerous risk factors and complications that might occur during diagnosis and treatment. Many regulatory systems, such as cell division, cell death, and metabolism, create tumor cells in the body. For more information, one can visit cbd news.
While studies have indicated that CBD has the potential to reduce numerous important glioblastoma risk factors, such as inflammation and blood pressure, the evidence for cancer prevention is still equivocal. On the other hand, CBD has gained favor in recent years as a treatment for the adverse effects of cancer treatment.